Health Benefits of Xanthones

Mangosteens Are Phytonutrient Rich

Like most fruits and vegetables, the mangosteen contains a wide assortment of plant-based nutriebts. In addition to anthocyanins, flavonoids, and terpenes, manggosteens are also rich in tannins and family of phytonutrients known as xanthones. Xanthones derive thir name from the Greek word "Xanthos," which means yellow due to their characteristic color in many plants (1). Xanthones, like polyphenois in fruits and vegetables, are a diverse family with at least 70 xanthones thus far isolated or characterized from mangosteen.

Health Benefits of the Mangosteen

In addition to its traditional use in treating various ailments, several clinicals studies suggest its health benefits. For example, two studies from Ohio State University reported consumption of commercial mangosteen-containing beverages that shownd bioavailablity of a -mangostin ( a major xanthone in the fruit ) as well as an increased antioxidant capacity in humans (2 ) (3). Similarly, these and other studies have also observed beneficial effects on immune system markers (4) (5). Most recently, researchers from Brazil found a significant improvement in insulin sensitivity in obese females consuming a mangosteen supplement, with no side effects (6). Finally, another clinical study confirmed increased absorption of xanthones from mangosteen when the fruit juice was consumed along with a high-fat meal (7),
which is unsurprising as many of these bioactive compounds are fat-soluble and therefore improved when consumed alongside dietary fat.

Overall, the company I am involved with can now add mangosteen-rich Xango Reserve to their health-supportive arsenal of high-quality shakes and bars, antioxidants, adaptogenic herbs, and other targeted solutions.

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2. Kondo M, Zhang L, Ji H, Kou Y, Ou B. Bioavailability and antioxidant effects of a xanthone-rich Mangosteen (Garcinia
mangostana) product in humans. J Agric Food Chem. 2009;57(19):8788-8792. doi:10.1021/jf901012f.
3. Xie Z, Sintara M, Chang T, Ou B. Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-
inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial. Food Sci Nutr.
  2015;3(4):342-348. doi:10.1002/fsn3.225.
4. Xie Z, Sintara M, Chang T, Ou B. Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-
  inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial. Food Sci Nutr.
  2015;3(4):342-348. doi:10.1002/fsn3.225.
5. Udani JK, Singh BB, Barrett ML, Singh VJ. Evaluation of Mangosteen juice blend on biomarkers of inflammation in obese
  subjects: a pilot, dose finding study. Nutr J. 2009;8:48. Published 2009 Oct 20. doi:10.1186/1475-2891-8-48.
6. Watanabe M, Gangitano E, Francomano D, et al. Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese
  Female Patients: A Prospective Randomized Controlled Pilot Study. Nutrients. 2018;10(5):586. Published 2018 May 9.
  doi:10.3390/nu10050586.
7. Chitchumroonchokchai C, Riedl KM, Suksumrarn S, Clinton SK, Kinghorn AD, Failla ML. Xanthones in mangosteen juice
  are absorbed and partially conjugated by healthy adults. J Nutr. 2012;142(4):675-680. doi:10.3945/jn.111.156992.

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